Reefer Madness (also known as Reefer Madness: The Movie Musical) premiered on April 16, 2005 on the Showtime cable network. It is a television movie version of the 2004 musical, and stars Alan Cumming as the Lecturer, Ana Gasteyer as Mae, and Kristen Bell as Mary. The movie also stars siblings Christian and Neve Campbell as Jimmy Harper and Miss Poppy. Kristen Bell, Christian Campbell, and John Kassir reprise their roles from the stage; Robert Torti, who played both Jack and Jesus on the stage, portrays only the latter in the movie version (Steven Weber plays Jack in the movie).

The film premiered at the 2005 Sundance Film Festival. It also screened in competition at the 2005 Deauville Film Festival and won the Premiere Audience Award. On the night of April 20, 2005, Showtime aired the musical back-to-back with the 1936 exploitation film that inspired it. The film won the 2005 Emmy Award for Music and Lyrics (for the song "Mary Jane/Mary Lane," which was written specially for the movie). It also received Emmy nominations for Choreography and Make-Up Effects. The movie was released on DVD on November 8, 2005.