House, also known as House, M.D., is an American television medical drama that debuted on the Fox network on November 16, 2004. The program was co-created by David Shore and Paul Attanasio; Fox officially credits Shore as creator. The show's central character is Dr. Gregory House (Hugh Laurie), an unconventional medical genius who heads a team of diagnosticians at the fictional Princeton‑Plainsboro Teaching Hospital (PPTH) in New Jersey. The character has similarities to Sherlock Holmes: both are forensic geniuses, musicians, drug users, aloof, and largely friendless. The show's premise originated with Attanasio, while Shore was primarily responsible for the conception of the title character. The show's executive producers include Shore, Attanasio, Attanasio's business partner Katie Jacobs, and film director Bryan Singer. It is largely filmed in Century City.

Dr. House often clashes with his boss, hospital administrator and Dean of Medicine Dr. Lisa Cuddy (Lisa Edelstein), and his diagnostic team, because many of his hypotheses about patients' illnesses are based on subtle or controversial insights. House's only true friend is Dr. James Wilson (Robert Sean Leonard), head of the Department of Oncology. During the first three seasons, House's diagnostic team consists of Dr. Robert Chase (Jesse Spencer), Dr. Allison Cameron (Jennifer Morrison), and Dr. Eric Foreman (Omar Epps). At the end of the third season, this team disbands. Rejoined by Foreman, House gradually selects three new team members: Dr. Remy "Thirteen" Hadley (Olivia Wilde), Dr. Chris Taub (Peter Jacobson), and Dr. Lawrence Kutner (Kal Penn). Along with Foreman, the other members of the original team still appear in different roles at the hospital; Kutner was written out of the series toward the end of season 5.